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    Neuron. 1988 Apr;1(2):127-32.

    Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.

    Kosik KS, Orecchio LD, Bruns GA, Benowitz LI, MacDonald GP, Cox DR, Neve RL.

    Department of Neurology (Neuroscience), Harvard Medical School, Boston, Massachusetts 02115.

    The growth-associated protein (GAP-43) is considered a crucial component of an effective regenerative response in the nervous system. Its phosphorylation by protein kinase C correlates with long-term potentiation. Sequence analysis of human cDNAs coding for this protein shows that the human GAP-43 gene is highly homologous to the rat gene; this homology extends into the 3'-untranslated region. However, the human protein contains a 10 amino acid insert. Somatic cell hybrids demonstrate localization of the GAP-43 gene to human chromosome 3 and to mouse chromosome 16.

    PMID: 3272162 [PubMed - indexed for MEDLINE]

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