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    J Biol Chem. 1988 Nov 15;263(32):16872-9.

    Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria.

    Kaufman EE, Nelson T, Fales HM, Levin DM.

    Department of Health and Human Services, National Institute of Mental Health, Bethesda, Maryland 20892.

    A transhydrogenase that catalyzes the oxoacid-dependent oxidation of specific hydroxyacids has been found in rat kidney, liver, and brain. The hydroxyacids that have been found to be substrates for this enzyme are gamma-hydroxybutyrate, D-alpha-hydroxyglutarate, and L-beta-hydroxybutyrate. The oxoacids that are the best substrates for this enzyme are alpha-ketoglutarate and succinic semialdehyde; alpha-ketoadipate and oxalacetate are also substrates. This enzyme is located in the mitochondrial fraction of the cell and is not dependent on added NAD+ or NADP+.

    PMID: 3182820 [PubMed - indexed for MEDLINE]

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