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    FEBS Lett. 1988 Nov 7;239(2):227-32.

    Islet amyloid polypeptide: identification and chromosomal localization of the human gene.

    Mosselman S, Höppener JW, Zandberg J, van Mansfeld AD, Geurts van Kessel AH, Lips CJ, Jansz HS.

    Institute of Molecular Biology, University of Utrecht, The Netherlands.

    Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.

    PMID: 3181427 [PubMed - indexed for MEDLINE]

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