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    Biochem Biophys Res Commun. 1987 Oct 29;148(2):617-22.

    Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.

    Uchida K, Morita T, Sato T, Ogura T, Yamashita R, Noguchi S, Suzuki H, Nyunoya H, Miwa M, Sugimura T.

    Virology Division, National Cancer Center Research Institute, Tokyo, Japan.

    The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3' untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.

    PMID: 3120710 [PubMed - indexed for MEDLINE]

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