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    Nature. 1988 Aug 25;334(6184):661-5.

    The molecular heterogeneity of protein kinase C and its implications for cellular regulation.

    Nishizuka Y.

    Department of Biochemistry, Kobe University School of Medicine, Japan.

    Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics. Some members of the family exhibit distinct patterns of tissue expression and intracellular localization; different kinases probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.

    PMID: 3045562 [PubMed - indexed for MEDLINE]

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