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    Mol Cell Biol. 1988 Jun;8(6):2651-4.

    B-raf, a new member of the raf family, is activated by DNA rearrangement.

    Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K.

    Department of Oncology, University of Tokyo, Japan.

    Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

    PMID: 3043188 [PubMed - indexed for MEDLINE]

    PMCID: 363468

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