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    Nucleic Acids Res. 1986 Feb 11;14(3):1379-91.

    Nucleotide sequence of the chicken 5-aminolevulinate synthase gene.

    Maguire DJ, Day AR, Borthwick IA, Srivastava G, Wigley PL, May BK, Elliott WH.

    5-Aminolevulinate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the nucleotide sequence. The structural gene is 6.9 kb long and contains 10 exons. The transcriptional start site for ALA-synthase was determined by primer extension analysis. A fragment of 291 bp from the 5' flanking region including 34 bp of the first exon shows promoter activity when introduced upstream of a chicken histone H2B gene and injected into the nuclei of Xenopus laevis oocytes.

    PMID: 3005973 [PubMed - indexed for MEDLINE]

    PMCID: 339511

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