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    Gene. 1985;36(3):357-62.

    Sequence comparison of human and murine erythrocyte alpha-spectrin cDNA.

    Curtis PJ, Palumbo A, Ming J, Fraser P, Cioe L, Meo P, Shane S, Rovera G.

    The results of hybridization analyses using cDNA probes for mouse and human alpha-spectrin mRNA indicate that a single gene encodes the alpha-subunit of erythrocyte spectrin. Sequencing of the cDNA clones showed that they code for 370 amino acids (aa) covering three repeat domains close to the C terminus of alpha-spectrin. The cloned cDNAs will now permit the isolation of the alpha-spectrin gene and should lead to the characterization of the genetic aspects in human hereditary anemias in which alpha-spectrin has been characterized as the site of the molecular defect.

    PMID: 3000887 [PubMed - indexed for MEDLINE]

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