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    Int J Biochem. 1985;17(5):645-8.

    Isolation and characterization of a cDNA and a pseudogene for mouse lactate dehydrogenase-A isozyme.

    Akai K, Yagi K, Tiano HF, Pan YC, Shimizu M, Fong K, Jungmann RA, Li SS.

    A mouse lactate dehydrogenase-A cDNA was isolated and it was shown to contain the 393bp of the protein-coding sequence and 488bp of the 3' untranslated region. The amino acid sequence deduced from its open reading frame provided independent evidence for the sequence of residues 201-331 of mouse LDH-A subunit (muscle). This cDNA clone was used as a probe to isolate a mouse genomic clone containing a truncated, processed LDH-A pseudogene. This pseudogene showed 81.6% homology at 713 positions compared with the LDH-A cDNA sequence. The divergence of this pseudogene was estimated to have occurred 39 million years ago.

    PMID: 2993055 [PubMed - indexed for MEDLINE]

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