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    J Biol Chem. 1985 Aug 25;260(18):10236-41.

    The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

    Sausville E, Carney D, Battey J.

    The human genes for prepro-arginine-vasopressin-neurophysin II (prepro-AVP-NPII) and prepro-oxytocin-neurophysin I (prepro-OT-NPI) were cloned from a human genomic library and the nucleotide sequence of both genes was determined. The two genes are similar in their intron-exon structure, linked together with 12 kilobases intervening, and transcribed from opposite DNA strands. A human small cell lung cancer cell line, H378, produces significant quantities of pre-pro-AVP-NPII mRNA using a transcription unit predicted from the genomic DNA sequence. Despite the proximity of the actively transcribed prepro-AVP-NPII gene, transcription of prepro-OT-NPI is not detected in this cell line.

    PMID: 2991279 [PubMed - indexed for MEDLINE]

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