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    J Biochem. 1987 Jul;102(1):13-6.

    Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells.

    Okano K, Aoki Y, Sakurai T, Kajitani M, Kanai S, Shimazu T, Shimizu H, Naruto M.

    Basic Research Laboratories, Toray Industries, Inc., Kanagawa.

    Medullasin, an inflammatory serine protease in bone marrow cells, modifies the functions of natural killer cells, monocytes, and granulocytes. We have cloned a medullasin cDNA from a human acute promyelocytic cell (ML3) cDNA library using oligonucleotide probes synthesized from the information of N-terminal amino acid sequence of natural medullasin. The cDNA contained a long open reading frame encoding 237 amino acid residues beginning from the second amino acid of natural meduallasin. The deduced amino acid sequence of medullasin shows a typical serine protease structure, with 41% homology with pig elastase 1.

    PMID: 2822677 [PubMed - indexed for MEDLINE]

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