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    Biochem Biophys Res Commun. 1989 Oct 16;164(1):439-45.

    Human alpha-L-fucosidase: complete coding sequence from cDNA clones.

    Occhiodoro T, Beckmann KR, Morris CP, Hopwood JJ.

    Department of Chemical Pathology, Adelaide Medical Centre for Women and Children, South Australia.

    The human lysosomal storage disorder fucosidosis results from the deficiency of alpha-L-fucosidase, a lysosomal enzyme essential for the catabolism of oligosaccharides containing alpha-L-fucosides. cDNA clones coding for human alpha-L-fucosidase have been isolated from lambda gt10 and lambda gt11 cDNA libraries derived from human liver, placenta and colon. Compilation of cDNA sequences results in a nucleotide sequence of 2053 base pairs encoding alpha-L-fucosidase. The sequence contains an open reading frame of 461 amino acids beginning with the first in-frame methionine and includes 439 amino acids which comprise the mature protein in addition to a hydrophobic signal peptide sequence of 22 amino acids.

    PMID: 2803312 [PubMed - indexed for MEDLINE]

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