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    Cell. 1989 Apr 7;57(1):71-8.

    Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain.

    Iwaki T, Kume-Iwaki A, Liem RK, Goldman JE.

    Department of Pathology, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032.

    Rosenthal fibers (RFs) are abnormal inclusions within astrocytes, characteristic of Alexander's disease. We have previously isolated a 22 kd protein component of RFs from Alexander's disease brain. By Western blotting, we detected its equivalent in several rat organs, with the highest level in heart, and in a human astrocytoma cell line (U-373MG). A cDNA library established from U-373MG was screened with an anti-RF protein antibody. A partial cDNA clone encoding the lens protein alpha B-crystallin was isolated. The anti-RF protein antibodies react with lens alpha B-crystallin. Furthermore, the distribution of alpha B-crystallin mRNA in rat organs is consistent with the Western blots. Therefore, alpha B-crystallin is not lens-specific and it can accumulate in large amounts in astrocytes in pathological conditions.

    PMID: 2539261 [PubMed - indexed for MEDLINE]

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