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    Mol Cell Biol. 1989 Oct;9(10):4550-5.

    Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA.

    Tsai AY, Streuli M, Saito H.

    Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.

    By alternative splicing, exons 4, 5, and 6 of the human leukocyte common antigen (LCA) gene are included in B-cell mRNA but excluded from thymocyte mRNA. A mini-LCA gene that contains only LCA exons 2, 6, and 8 faithfully reproduces this tissue-specific alternative splicing in mouse B and thymocyte cell lines. Elimination of almost all of the intron sequences associated with exon 6 had no effect on the alternative splicing, while linker-scanning analysis showed that a significant length of the exon 6 sequence is essential for alternative splicing.

    PMID: 2531281 [PubMed - indexed for MEDLINE]

    PMCID: 362542

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