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    Biochim Biophys Acta. 1989 Dec 22;1009(3):283-6.

    Characteristic sequences in the upstream region of the human tyrosinase gene.

    Kikuchi H, Miura H, Yamamoto H, Takeuchi T, Dei T, Watanabe M.

    Department of Cancer Chemotherapy and Prevention, Research Institute for Tuberculosis and Cancer, Sendai, Japan.

    A human tyrosinase gene containing a 5'-flanking region and the first exon was isolated from a normal human liver library using mouse tyrosinase cDNA as a probe for screening. In the 5'-upstream region of transcriptional start sites, there is a putative TATA box and CAAT box and some palindromic sequences. A characteristic sequence of (GA:TCn, which can assume a hinged-DNA structure, was present from -869 nt to -633 nt in this 5'-flanking region.

    PMID: 2480811 [PubMed - indexed for MEDLINE]

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