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    Oncogene. 1989 Apr;4(4):429-36.

    Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells.

    Brookes S, Smith R, Casey G, Dickson C, Peters G.

    Imperial Cancer Research Fund Laboratories, St. Bartholomew's Hospital, London, UK.

    We report the genomic organization and DNA sequence of the human homologue of int-2, a proto-oncogene implicated in virally induced mammary tumours in the mouse, and expressed at specific sites and times during embryogenesis. Direct comparisons with the coding domains of mouse int-2 allowed us to delineate the intron-exon boundaries of the human gene. These boundaries were subsequently confirmed by ribonuclease protection analyses of the single 1.7 kilobase (kb) int-2 transcript detectable in the human teratocarcinoma cell line, Tera-2. The data suggest that human int-2 may also function in embryonic lineages but that its transcription may be less complex than in the mouse. The predicted human protein comprises 239 amino acids and is 89% homologous to its murine counterpart, except at the carboxy terminus. This divergence occurs distal to the region of int-2 that shows homology to other members of the FGF family of growth modulators and oncogenes.

    PMID: 2470007 [PubMed - indexed for MEDLINE]

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