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    FEBS Lett. 1990 Jun 18;266(1-2):163-6.

    Antithrombin Rouen-IV 24 Arg----Cys. The amino-terminal contribution to heparin binding.

    Borg JY, Brennan SO, Carrell RW, George P, Perry DJ, Shaw J.

    Laboratoire d'hemostase, Centre Hospitalier Universitaire, Rouen, France.

    A variant antithrombin with reduced heparin affinity was shown by mass spectrometry sequencing and DNA amplification to have a substitution of a cysteine for an arginine at residue 24. The position of Arg-24 can be fixed within a 12 A radius from the bridge at Cys-21. This is compatible with findings in the homologous protease nexin-1 which indicate an extension of the binding site of heparin from the D-helix to under the adjacent amino-terminal pole.

    PMID: 2365065 [PubMed - indexed for MEDLINE]

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