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    Nature. 1990 Nov 29;348(6300):419-26.

    Crystal structure of an HIV-binding recombinant fragment of human CD4.

    Ryu SE, Kwong PD, Truneh A, Porter TG, Arthos J, Rosenberg M, Dai XP, Xuong NH, Axel R, Sweet RW, et al.

    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032.

    Comment in:

    CD4 glycoprotein on the surface of T cells helps in the immune response and is the receptor for HIV infection. The structure of a soluble fragment of CD4 determined at 2.3 A resolution reveals that the molecule has two intimately associated immunoglobulin-like domains. Residues implicated in HIV recognition by analysis of mutants and antibody binding are salient features in domain D1. Domain D2 is distinguished by a variation on the beta-strand topologies of antibody domains and by an intra-sheet disulphide bridge.

    PMID: 2247146 [PubMed - indexed for MEDLINE]

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