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    Oncogene. 1990 Mar;5(3):267-75.

    Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.

    Alcalay M, Antolini F, Van de Ven WJ, Lanfrancone L, Grignani F, Pelicci PG.

    Istituto di Clinica Medica I, University of Perugia, Italy.

    cDNA clones of the human c-fes mRNA were isolated. Nucleotide analysis showed that c-fes mRNA contains a 2514 nucleotide open reading frame, which could encode for a 93 kDa protein, and both 5' and 3' v-fes nonhomologous sequences. Primer extension experiments confirmed that the longest isolated cDNAs are about the same length as the entire human c-fes mRNA. Sequence comparison between human c-fes cDNA and the corresponding genomic regions identified a 5' viral-non homologous exon (exon 1) located 491 bp upstream from the first v-fes homologous exon. The genomic region surrounding c-fes exon 1 contains a CpG island and acts as a promoter in vitro. Analysis of the 5' end of mouse c-fes cDNA suggested that the 5' human and mouse gene structure are similar.

    PMID: 2179816 [PubMed - indexed for MEDLINE]

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