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    Science. 1990 Nov 2;250(4981):651-7.

    Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H(+)-adenosine triphosphatase.

    Kane PM, Yamashiro CT, Wolczyk DF, Neff N, Goebl M, Stevens TH.

    Institute of Molecular Biology, University of Oregon, Eugene 97403.

    The TFP1 gene of the yeast Saccharomyces cerevisiae encodes two proteins: the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H(+)-ATPase) and a 50-kD protein. The 69-kD subunit is encoded by the 5' and 3' thirds of the TFP1 coding region, whereas the 50-kD protein is encoded by the central third. Evidence is presented that both the 69-kD and 50-kD proteins are obtained from a single translation product that is cleaved to release the 50-kD protein and spliced to form the 69-kD subunit.

    PMID: 2146742 [PubMed - indexed for MEDLINE]

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