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    Biochemistry. 1990 Oct 23;29(42):9814-8.

    NADPH-cytochrome P-450 oxidoreductase gene organization correlates with structural domains of the protein.

    Porter TD, Beck TW, Kasper CB.

    McArdle Laboratory for Cancer Research, University of Wisconsin-Madison 53706.

    cDNA clones to rat liver NADPH-cytochrome P-450 oxidoreductase were used to isolate genomic clones from a Wistar-Furth inbred rat genomic DNA library. Fifteen exons containing the coding region and 3'-nontranslated segment of the P-450 reductase gene were identified, spanning 20 kilobases of DNA contained in 3 lambda-Charon 35 clones. The organization of this single copy gene reveals a general correspondence between exons and structural domains of the protein, with the segment responsible for anchoring the reductase to the microsomal membrane and several segments involved in FMN, FAD, and NADPH binding encoded by discrete exons.

    PMID: 2125483 [PubMed - indexed for MEDLINE]

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