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    Regul Pept. 1990 Dec 10;31(3):179-86.

    Isolation and identification of islet amyloid polypeptide in normal human pancreas.

    Nakazato M, Asai J, Miyazato M, Matsukura S, Kangawa K, Matsuo H.

    Third Department of Internal Medicine, Miyazaki Medical College, Japan.

    To identify islet amyloid polypeptide (IAPP) present in normal human pancreas, we isolated the peptide from a soluble peptide fraction of amyloid deposit-free pancreata of two non-diabetic patients by using reverse-phase high performance liquid chromatography coupled with a radioimmunoassay specific for human IAPP. IAPP(1-37) and IAPP(17-37) were isolated and their complete amino acid sequences were determined up to the C-terminus. Identification of IAPP in normal human pancreas suggests the possible biological function of IAPP as a novel pancreatic hormone in humans.

    PMID: 2091067 [PubMed - indexed for MEDLINE]

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