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    Biochem Biophys Res Commun. 1991 Jun 28;177(3):979-84.

    Fast-twitch and slow-twitch skeletal muscles express the same isoform of calreticulin.

    Fliegel L, Michalak M.

    Department of Biochemistry, University of Alberta, Edmonton, Canada.

    We have characterized calreticulin protein and mRNA in fast-twitch and slow-twitch skeletal muscle. SR vesicles isolated from fast-twitch and slow-twitch skeletal muscles contain calreticulin protein immunoreactive with anti-calreticulin antibody. In addition, the fast-twitch skeletal muscle form of calreticulin is shown to be identical to slow-twitch form of the protein based on the identity of cDNA clones encoding fast-twitch and slow-twitch forms of the protein and hybridization of a fast-twitch or slow-twitch calreticulin cDNA probe to the same mRNA species. Based on these observations we conclude that fast-twitch and slow-twitch skeletal muscles express the same form of calreticulin.

    PMID: 2059224 [PubMed - indexed for MEDLINE]

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    • ReviewCalreticulin.

      Michalak M, Milner RE, Burns K, Opas M. Biochem J. 1992 Aug 1; 285 ( Pt 3):681-92.

      [Biochem J. 1992]

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