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    Biochem Biophys Res Commun. 1991 Apr 30;176(2):792-7.

    A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse.

    Tsutsui J, Uehara K, Kadomatsu K, Matsubara S, Muramatsu T.

    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan.

    A retinoic acid responsive gene, MK, specifies for a heparin binding factor termed midkine (MK), which is the initial member of a new protein family involved in regulation of growth and differentiation. A cDNA clone of human MK was isolated from a fetal kidney cDNA library. Human MK mRNA was expressed in PA1 teratocarcinoma cells as well as in the kidney. Sequence analysis of the cDNA clone and of a part of the genomic clone yielded the predicted protein sequence of human MK. Human and mouse MK sequences are highly conserved: 87% of amino acids are identical and all amino acid changes are conservative except for an insertion. Comparison of MK and HB-GAM/pleiotrophin (another member of the family) from various species revealed sequences conserved in the family and those specific for each protein.

    PMID: 2025291 [PubMed - indexed for MEDLINE]

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