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    Gene. 1991 Feb 1;98(1):141-5.

    Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1.

    Morris ME, Jinks-Robertson S.

    Department of Biology, Emory University, Atlanta, GA 30322.

    The Saccharomyces cerevisiae LYS2 gene, which encodes alpha-aminoadipate reductase, an essential enzyme in the yeast lysine biosynthetic pathway, has been sequenced. A large open reading frame (ORF) has been identified which can specify a 1392-amino acid protein with a deduced Mr of 155,344. A DNA database search using the translated LYS2 ORF as a probe has revealed significant aa sequence homology to the Bacillus brevis enzyme tyrocidine synthetase 1.

    PMID: 2013406 [PubMed - indexed for MEDLINE]

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