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    Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):502-6.

    Crystal structure of interleukin 8: symbiosis of NMR and crystallography.

    Baldwin ET, Weber IT, St Charles R, Xuan JC, Appella E, Yamada M, Matsushima K, Edwards BF, Clore GM, Gronenborn AM, et al.

    Crystallography Laboratory, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702.

    The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding.

    PMID: 1988949 [PubMed - indexed for MEDLINE]

    PMCID: 50839

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