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    Nature. 1991 Sep 26;353(6342):321-5.

    The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation.

    Madden DR, Gorga JC, Strominger JL, Wiley DC.

    Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, Massachusetts.

    X-ray crystallography reveals electron density in the antigen-binding site of HLA-B27 that is an interpretable image of nonameric peptides in a largely extended conformation. Clear density exists for the main chain and several side chains and is consistent with the sequence of 11 nonameric self-peptides eluted from HLA-B27. Pockets in the antigen-binding cleft bind four side chains and the amino and carboxyl termini of the peptide.

    PMID: 1922337 [PubMed - indexed for MEDLINE]

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