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    Science. 1991 May 3;252(5006):698-702.

    Three-dimensional structure of recombinant human interferon-gamma.

    Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE.

    Department of Pharmacology, University of Alabama, Birmingham 35294.

    The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions.

    PMID: 1902591 [PubMed - indexed for MEDLINE]

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