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    J Bacteriol. 1991 May;173(10):3228-30.

    Analysis of a Corynebacterium glutamicum hom gene coding for a feedback-resistant homoserine dehydrogenase.

    Reinscheid DJ, Eikmanns BJ, Sahm H.

    Institut für Biotechnologie, 1 des Forschungszentrums Jülich GmbH, Federal Republic of Germany.

    From a Corynebacterium glutamicum mutant possessing a homoserine dehydrogenase resistant to feedback inhibition by L-threonine, the corresponding gene (homFBR) was analyzed and compared with the wild-type hom gene. DNA fragment exchange experiments between both genes showed that a 0.23-kb region close to the 3' terminus of homFBR was responsible for deregulation. Nucleotide sequence analysis revealed a single transition from G to A in homFBR leading to replacement of glycine-378 by glutamate in the mutant homoserine dehydrogenase.

    PMID: 1902466 [PubMed - indexed for MEDLINE]

    PMCID: 207919

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