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    Science. 1991 Feb 15;251(4995):802-4.

    Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.

    Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA.

    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.

    Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF.

    PMID: 1846706 [PubMed - indexed for MEDLINE]

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