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    Cell. 1991 Sep 20;66(6):1217-28.

    Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.

    Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM.

    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

    A new human cyclin, named cyclin E, was isolated by complementation of a triple cln deletion in S. cerevisiae. Cyclin E showed genetic interactions with the CDC28 gene, suggesting that it functioned at START by interacting with the CDC28 protein. Two human genes were identified that could interact with cyclin E to perform START in yeast containing a cdc28 mutation. One was CDC2-HS, and the second was the human homolog of Xenopus CDK2. Cyclin E produced in E. coli bound and activated the CDC2 protein in extracts from human G1 cells, and antibodies against cyclin E immunoprecipitated a histone H1 kinase from HeLa cells. The interactions between cyclin E and CDC2, or CDK2, may be important at the G1 to S transition in human cells.

    PMID: 1833068 [PubMed - indexed for MEDLINE]

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