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    Protein Pept Lett. 2008;15(1):43-6.

    Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin.

    Rüggeberg S, Horn P, Li X, Vajkoczy P, Franz T.

    European Molecular Biology Laboratory, Proteomic Core Facility, Meyerhofstr. 1. 69117 Heidelberg, Germany.

    During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the gamma-carboxylation of the Glu-42 (Gla-42).

    PMID: 18221012 [PubMed - indexed for MEDLINE]

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