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    Antimicrob Agents Chemother. 2008 Mar;52(3):1133-5. Epub 2007 Dec 10.

    Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.

    Henriquez FL, Ingram PR, Muench SP, Rice DW, Roberts CW.

    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, United Kingdom. fiona.henriquez@paisley.ac.uk

    Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.

    PMID: 18070965 [PubMed - indexed for MEDLINE]

    PMCID: 2258519

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