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    Nat Struct Mol Biol. 2007 Aug;14(8):710-5. Epub 2007 Jul 22.

    CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.

    Kim H, Huang J, Chen J.

    Department of Therapeutic Radiology, Yale University School of Medicine, P.O. Box 208040, New Haven, Connecticut 06520, USA.

    The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.

    PMID: 17643122 [PubMed - indexed for MEDLINE]

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