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    Biochemistry. 1991 May 14;30(19):4774-89.

    Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein.

    Rosen MK, Michnick SW, Karplus M, Schreiber SL.

    Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138.

    Sequential 1H and 15N assignments of human FKBP, a cytosolic binding protein for the immunosuppressive agents FK506 and rapamycin, are reported. A combination of homonuclear and relayed heteronuclear experiments has enabled assignment of 98 of 99 backbone amide NHs, 119 of 120 C alpha Hs, 97 of 99 non-proline amide 15Ns, and 375 of 412 side-chain resonances of this 107-residue protein. Long-range NOEs are used to demonstrate that FKBP has a novel folding topology consisting of a five-stranded antiparallel beta sheet with +3, +1, -3, +1 loop connectivity.

    PMID: 1709363 [PubMed - indexed for MEDLINE]

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