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    Nature. 1990 Nov 29;348(6300):411-8.

    Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.

    Wang JH, Yan YW, Garrett TP, Liu JH, Rodgers DW, Garlick RL, Tarr GE, Husain Y, Reinherz EL, Harrison SC.

    Harvard University, Department of Biochemistry and Molecular Biology, Cambridge, Massachusetts.

    Comment in:

    The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.

    PMID: 1701030 [PubMed - indexed for MEDLINE]

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