Nature. 1990 Nov 29;348(6300):411-8.

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.

Wang JH, Yan YW, Garrett TP, Liu JH, Rodgers DW, Garlick RL, Tarr GE, Husain Y, Reinherz EL, Harrison SC.

Harvard University, Department of Biochemistry and Molecular Biology, Cambridge, Massachusetts.

Comment in:

Nature. 1990 Nov 29;348(6300):393-4.

The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.

PMID: 1701030 [PubMed - indexed for MEDLINE]

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Crystal structure of an HIV-binding recombinant fragment of human CD4.
Nature. 1990 Nov 29; 348(6300):419-26.

[Nature. 1990]
Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.
Proc Natl Acad Sci U S A. 1990 Nov; 87(22):9052-6.

[Proc Natl Acad Sci U S A. 1990]
Structural mimicry of CD4 by a cross-reactive HIV-1 neutralizing antibody with CDR-H2 and H3 containing unique motifs.
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[J Mol Biol. 2006]
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[Cold Spring Harb Symp Quant Biol. 1992]
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Curr Opin Biotechnol. 1991 Aug; 2(4):622-33.

[Curr Opin Biotechnol. 1991]
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Cited by over 100 PubMed Central articles

Structure of a V3-containing HIV-1 gp120 core.
Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, et al. Science. 2005 Nov 11; 310(5750):1025-8.

[Science. 2005]
NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition.
Ames JB, Vyas V, Lusin JD, Mariuzza R. Biochemistry. 2005 May 3; 44(17):6416-23.

[Biochemistry. 2005]
Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.
Xiang SH, Kwong PD, Gupta R, Rizzuto CD, Casper DJ, Wyatt R, Wang L, Hendrickson WA, Doyle ML, Sodroski J. J Virol. 2002 Oct; 76(19):9888-99.

[J Virol. 2002]
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Structures reported by this article

Refinement And Analysis Of The First Two Domains Of Human Cd4

PDB: 3CD4

Source: Homo sapiens

Method: X-Ray Diffraction | Resolution: 2.2 Å

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