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    FEBS Lett. 2006 Jul 10;580(16):3953-60. Epub 2006 Jun 21.

    Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue.

    Kim KY, Kim HY, Kim JH, Lee CH, Kim DH, Lee YH, Han SH, Lim JS, Cho DH, Lee MS, Yoon S, Kim KI, Yoon DY, Yang Y.

    Department of Life Science, Research Center for Women's Diseases, Sookmyung Women's University, Seoul 140-742, Republic of Korea.

    CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-alpha and IL-1beta. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.

    PMID: 16806199 [PubMed - indexed for MEDLINE]

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