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    Biochem Biophys Res Commun. 1991 Mar 29;175(3):906-13.

    Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture.

    Yamanishi K, Liew FM, Konishi K, Yasuno H, Doi H, Hirano J, Fukushima S.

    Department of Dermatology, Kyoto Prefectural University of Medicine, Japan.

    We have isolated a cDNA encoding human epidermal transglutaminase, a key enzyme of terminal differentiation of keratinocytes. A cDNA library from cultured human keratinocytes was screened by a PCR-amplified partial cDNA fragment of the enzyme with oligonucleotide primers based on the homology of the transglutaminase family. The cDNA is 2734 bp coding a protein of 817 amino acids. The several regions including the active site cysteine residue are highly conserved among the transglutaminase family. However, the charged N-terminal domain is unique to the epidermal transglutaminse, suggesting that the region is involved in the function of the enzyme in keratinocytes.

    PMID: 1673840 [PubMed - indexed for MEDLINE]

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