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    Am J Hum Genet. 2006 Jun;78(6):1060-5. Epub 2006 Apr 14.

    Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.

    Ekelund E, Saaf A, Tengvall-Linder M, Melen E, Link J, Barker J, Reynolds NJ, Meggitt SJ, Kere J, Wahlgren CF, Pershagen G, Wickman M, Nordenskjold M, Kockum I, Bradley M.

    Department of Molecular Medicine and Surgery, Department of Medicine, Karolinska University Hospital, Stockholm, SE-171 76, Sweden.

    In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.

    PMID: 16685656 [PubMed - indexed for MEDLINE]

    PMCID: 1474106

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