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    Endocr J. 2005 Oct;52(5):643-5.

    Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism.

    Tajima T, Tsubaki J, Fujieda K.

    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.

    We encountered a Japanese patient with goitrous hypothyroidism due to iodide organification defect in the thyroid gland. Sequence analysis identified two novel mutations (E378K in exon 8 and a heterozygous 10 base deletion of the intron 15-exon 16 boundary) in the thyroid peroxidase (TPO) gene. As individuals with goitrous hypothyroidism caused by TPO gene mutation develop thyroid cancer, regular and careful follow-up for such patients must be done.

    PMID: 16284446 [PubMed - indexed for MEDLINE]

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    • Thyroid (Armour® Thyroid)

      Thyroid is a hormone produced by the body. When taken correctly, thyroid is used to treat the symptoms of hypothyroidism (a condition where the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyr...

    • Source: AHFS Consumer Medication Information

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