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    Biochim Biophys Acta. 1992 Jul 15;1131(3):329-32.

    The cDNA cloning and mRNA expression of rat protein C.

    Okafuji T, Maekawa K, Nawa K, Marumoto Y.

    Molecular Biology Research Laboratory, Daiichi Pharmaceutical Co., Tokyo, Japan.

    We cloned a cDNA coding for rat protein C, which provides hybridization probes for the detection of protein C mRNA in several tissues. The cloned cDNA was 1543 bp long and contained a single open reading frame of 1383 nucleotides. The proposed rat protein C precursor contained 461 amino acid residues: a 41 amino acid preproleader sequence, and light (155 amino acids) and heavy (263 amino acids) chains joined by a Lys-Arg dipeptide. Northern blot analysis showed that the rat protein C mRNA was expressed not only in the liver, but also in the kidney.

    PMID: 1627650 [PubMed - indexed for MEDLINE]

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