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    Nucleic Acids Res. 1992 Apr 25;20(8):1967-72.

    Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3.

    Lu D, Yunis JJ.

    Department of Neoplastic Diseases, Hahnemann University, Philadelphia, PA 19102-1192.

    A gene encoding a putative human RNA helicase, p54, has been cloned and mapped to the band q23.3 of chromosome 11. The predicted amino acid sequence shares a striking homology (75% identical) with the female germline-specific RNA helicase ME31B gene of Drosophila. Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.

    PMID: 1579499 [PubMed - indexed for MEDLINE]

    PMCID: 312313

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