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    Genes Dev. 2004 Dec 15;18(24):3004-9. Epub 2004 Dec 1.

    The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.

    Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R.

    Elixir Pharmaceuticals, Cambridge, Massachusetts 02139, USA. japfeld@elixirpharm.com

    Erratum in:

    • Genes Dev. 2005 Feb 1;19(3):411.
    • Genes Dev. 2005 Jan 1;19(1):188.

    Although limiting energy availability extends lifespan in many organisms, it is not understood how lifespan is coupled to energy levels. We find that the AMP:ATP ratio, a measure of energy levels, increases with age in Caenorhabditis elegans and can be used to predict life expectancy. The C. elegans AMP-activated protein kinase alpha subunit AAK-2 is activated by AMP and functions to extend lifespan. In addition, either an environmental stressor that increases the AMP:ATP ratio or mutations that lower insulin-like signaling extend lifespan in an aak-2-dependent manner. Thus, AAK-2 is a sensor that couples lifespan to information about energy levels and insulin-like signals.

    PMID: 15574588 [PubMed - indexed for MEDLINE]

    PMCID: 535911

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