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    Mol Biol Rep. 2004 Sep;31(3):191-5.

    Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1.

    Ye X, Ji C, Zhou C, Zeng L, Gu S, Ying K, Xie Y, Mao Y.

    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China.

    Mitochondrial fatty acid beta-oxidation is an important energy resource for many mammal tissues. Acyl-CoA dehydrogenases (ACADs) are a family of flavoproteins that are involved in the beta-oxidation of the fatty acyl-CoA derivatives. Deficiency of these ACADs can cause metabolic disorders including muscle fatigue, hypoglycaemia, hepatic lipidosis and so on. By large scale sequencing, we identified a cDNA sequence of 3960 base pairs with a typical acyl-CoA dehydrogenase function domain. RT-PCR result shows that it is widely expressed in human tissues, especially high in liver, kidney, pancreas and spleen. It is hypothesized that this is a novel member of ACADs family.

    PMID: 15560374 [PubMed - indexed for MEDLINE]

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