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    FEBS Lett. 1992 Feb 3;297(1-2):107-11.

    Cloning and expression of a bovine adenosine A1 receptor cDNA.

    Tucker AL, Linden J, Robeva AS, D'Angelo DD, Lynch KR.

    Department of Biochemistry, University of Virginia, Charlottesville 22908.

    A bovine brain adenosine A1 receptor cDNA encoding a 326 amino acid protein has been identified. This cDNA, which encodes a protein greater than 90% identical to analogous rat and dog receptors, was transiently expressed in COS-1 cells. Recombinant receptors exhibited the features of bovine A1 receptors that distinguish it from rat and canine receptors, including subnanomolar Ki for 1,3-dipropyl-8-cyclopentylxanthine, R-phenylisopropyl- adenosine (R-PIA) and xanthine amino conjugate, and the distinct potency order: R-PIA greater than S-PIA much greater than 5'-N-ethylcarboxamidoadenosine greater than 2'-chloroadenosine. The results indicate that the pharmacological differences between A1 adenosine receptors among species result from only minor differences in receptor structures.

    PMID: 1551415 [PubMed - indexed for MEDLINE]

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