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    J Mol Biol. 2004 Oct 15;343(2):407-16.

    Apo and inhibitor complex structures of BACE (beta-secretase).

    Patel S, Vuillard L, Cleasby A, Murray CW, Yon J.

    Astex Technology, 436 Cambridge Science Park, Milton Road, CB4 0QA, UK.

    Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 A, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design.

    PMID: 15451669 [PubMed - indexed for MEDLINE]

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