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    Biochim Biophys Acta. 2004 Aug 4;1689(3):175-8.

    Interaction of ACE2 and integrin beta1 in failing human heart.

    Lin Q, Keller RS, Weaver B, Zisman LS.

    The Center for Functional Genomics, Proteomics Core Facility, University at Albany, Rensselaer, NY, USA.

    ACE2 purified from failing human heart was found to form a complex with integrin beta1 by immunoprecipitation, Western blotting, activity assay, and ESI tandem mass spectroscopy. The ACE2/integrin complex showed a Km of 6.8 microM and a Vmax of 2.13 pmol/min/microl purified enzyme. Activity was optimal at pH 7.5 with Ang II substrate.

    PMID: 15276642 [PubMed - indexed for MEDLINE]

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