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    Biochem Biophys Res Commun. 2004 Jul 30;320(3):760-5.

    Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.

    La M, Kim K, Park J, Won J, Lee JH, Fu YM, Meadows GG, Joe CO.

    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, Republic of Korea.

    Daxx-mediated transcriptional repression was modulated by a speckled POZ domain protein SPOP which was first identified as an autoantigen from the serum of a scleroderma patient. This is the first report on the biochemical and functional interactions between Daxx and SPOP. The COOH-terminal region of Daxx interacts with the NH2-terminal region of SPOP. SPOP reversed the transcriptional repression mediated by Daxx which binds with ETS1 transcription factor to repress ETS1-responsive gene expression. Mutagenesis study suggests that the ability of SPOP to self-associate as well as its ability to bind with Daxx was important for the modulation of Daxx-mediated transcriptional repression.

    PMID: 15240113 [PubMed - indexed for MEDLINE]

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