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    Mol Biochem Parasitol. 1992 Aug;54(1):63-72.

    Inter-species variation of schistosome 28-kDa glutathione S-transferases.

    Trottein F, Godin C, Pierce RJ, Sellin B, Taylor MG, Gorillot I, Silva MS, Lecocq JP, Capron A.

    Centre d'Immunologie des Maladies Transmissibles et Allergiques, Unité mixte INSERM 167-CNRS 624, Institut Pasteur, Lille, France.

    The 28-kDa glutathione S-transferase from Schistosoma mansoni (Sm28GST) is a candidate vaccine antigen. To evaluate the antigenic and phylogenetic variations between the 28-kDa GSTs from 4 species of schistosome, we have cloned and sequenced the 28-kDa GSTs from Schistosoma haematobium (Sh28GST) and Schistosoma bovis (Sb28GST). Sb28GST and Sh28GST are more similar to each other (97%) than to Sm28GST (90%) and particularly to the 28-kDa GST from Schistosoma japonicum (Sj28GST, 77%). Antisera directed against the major Sm28GST epitopes revealed differences in the recognition of the 28-kDa GSTs from the other schistosome species suggesting that these regions have been subjected to evolutionary pressure. The consequences of such species-specific epitopes on the development of a multi-species anti-schistosome vaccine are discussed.

    PMID: 1518533 [PubMed - indexed for MEDLINE]

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