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    Biochim Biophys Acta. 1992 Dec 29;1171(2):215-8.

    Nucleotide sequence of a complementary DNA for human ST2.

    Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T.

    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.

    Human ST2 cDNA, a homologue of murine ST2 that is only expressed in growth-stimulated BALB/c-3T3 cells and a member of the primary response gene family induced by growth factors, was isolated from the cDNA library of an activated human helper T cell line, 5C10. Human ST2 has 67.6% identity in a 327 amino acid overlap to murine ST2. Furthermore, as in the case of murine ST2, human ST2 encodes a protein remarkably similar in sequence to the extracellular portion of human interleukin 1 receptor, both types 1 and 2. The expression of ST2 in human lymphocytes could trigger further investigations into its physiological role in humans.

    PMID: 1482686 [PubMed - indexed for MEDLINE]

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